So I noticed you have changed the radiator have you replaced the thermostat? I pulled my father in-law's ford 3000 up I540(I49) from Fort Smith (Probably 7500 lbs with trailer) and the truck did not like the grades at all. My temps spiked really fast. I bought a couple of the motorcraft thermostats and have been meaning to replace mine. I have noticed that my truck unloaded runs at 220 constantly(according to my aftermarket gage the PO put in). I'll end up doing all the tests with the radiator surface temps, fan clutch etc to get it all figured out.
my truck used to run 220 all the time. summer, winter, idling would overheat when really hot, crusing hiway at 230 unloaded. Had alum radiator.
Same engine, same wp, same radiator, but new motorcraft fan clutch and motorcraft thermostat, i havent seen over 192F moving 2000# of stuff in the bed, hardly heavy but this new stat and fan clutch wellllllll worth it. 18-19 mpg still