B100/B99 is a totally different beast from WVO, mainly because the glycerol stays in the WVO and that increases BTU/unit. It also increases acrolein emissions and makes the fuel thick compared to dino or biodiesel. I would suggest you'll get very close to the same fuel economy you get on diesel on the highway similarly loaded and with similar speeds. I do not know what that is since you haven't told us and no guesses either since I don't know the specifics of your rig. Personally I get 12-14 mpg on B100 around town and 15+, usually closer to 16 or better if I'm not heavy and it's all highway driving 65 or less, this is with 3.55s and no OD. Probably would be slightly better with diesel fuel and maybe somewhat better with WVO as the methanol or ethanol that replaces the glycerides in the oils don't have quite the BTUs of what they replaced.