Let my guess, you have a 1988 or early '89 F-Super Duty?
My shop has an 88 F450 Diesel with the C6/5.13's as a yard truck, it has a transport truck 5th wheel on it, and it's used for moving around transport truck trailers in the yard and around.
It has a top speed of 70km/h (45mph)
If your easy on the gas, the C6 will shift 1-2-3 before you cross an intersection
If I were you, I'd leave the C6 with the GV unit. That would be your strongest automatic setup you can ask for!
Like others said, you can built up a E4OD to be bullet proof, but you better have deep pockets for that option....
Best thing would be a ZF5 5 speed standard swap, and add the GV unit to that!