This is a common problem with these rearends. Later on Ford extended the nose of the rearend to try to fix it. What happens is the splines wear a little bit that engage the yoke to the pinion shaft. As the splines work a little bit back and forth, they start loosening the nut. When it gets loose enough, you will start noticing a little driveline vibration and possibly a small oil leak around the pinion seal.
The one I worked on recently I pulled apart, and it seems like the yoke splines where worn a little bit more than the pinion shaft, and I believe a new yoke piece may have permanently repaired it, but the guy who owned the truck didn't want to spend the money, and just wanted me to tighten it back up. I put my impact on it's highest setting and tightened the nut back up, and it has been holding ok for awhile now.