I have a gallon of anchor 501 saf-t-gard that was given to me when I bought my flatbed.
I plan to just get a cheap HF blaster to do it.
I wire wheeled the frame and used the rust-oleum rust preventative primer, also got a gloss top coat, just haven't done it yet. Though I did do a test area.
IMO, wire wheeling would take way to long on a flatbed. Especially if you're doing the under side also.