85 250/c6 Did 2 900 mile trips, no problems.
83 250/t19 did multiple 700 mile trips. Lost a rod bearing one time, multiple broken injector lines, intermittent tail lights, brake wedges liked to pop out.
In all of my vehicles on a long trip I keep a full tool kit including wiring, multimeter, sockets, wrenches, prybars, jacks, belts, jump pack, any vehicle specific parts (spark plugs and coil packs in the car, injector lines, fuel hoses, and filters in the truck), fire extinguisher and a high vis vest.