Not all 80-97 trucks have a removable floor pan, for certain at least 80-86 2wd automatic or column shift 3 speed trucks had a solid panel, with the stamping that the removable plate is in place. I've swapped a few three on the tree trucks to 4 speed, and it was a matter of drill the holes, then cut about 1/2" inside of them to create the access hole. I know an insert for the older slushboxes isn't tall enough, but, an E4OD is a huge mother compared, so, it may be tall enough. I know on a Super Duty, the whole tunnel is different auto vs. stick(manual is quite a bit bigger) like the old GM 2wd/4wd cab difference. Of course, the solution to all of this is a body lift...
The 87+ trucks run the transfer case shift lever through a hole in the main floor pan, about 6" further left than the 80-86 trucks do. That will be there 2wd or not, just need to unbolt the block off plate and bolt on the boot.
As for the clutch master mounting, the block off plate is at the oldest 87+, possibly even newer. 82-86 trucks do have the re-enforcement plate on the firewall drilled, so you just have to drill the firewall itself using the holes in the re-enforcement plate as a guide. That's what I did on the 82 cab(the BBF powered F250 now)
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Unfortunately, I can't find any before pictures. That cab started life with a linkage clutch. I got lucky and found an 82 with an auto and was able to steal it's plug for the linkage hole.
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The diesel, the cab is an 81, so, it wasn't marked in any way, so, I cut the section out of the firewall from the factory cab to use as a guide... It didn't make it 2 years before it cracked up bigtime, whereas 5 years down the road I've never had an issue with the gasser....