I don't think you'd see a measurable difference, except in the weight of your wallet. If you wanted to eliminate rotating mass, consider the flywheel (if manual). A manual transmission flyhweel is really heavy, and takes a lot energy to spin it up and keep it spinning. Actually, it doesn't take that much, but certainly a lot more than a driveshaft spinning 2-3" away from its center of rotation. And if you don't already have a manual, swapping one in would be a good 1st step, as would lightening the whole truck. Then running narrow tires at full pressure. But most of us don't run these trucks for getting good mileage, or we'd all be in Jetta TDIs or at least anything but a 20 year old V-8 diesel with the aerodynamic profile of a brick.