You are good as long as the bed stays grounded to the frame and the frame is grounded. I think the factory ran a ground wire all the way up front to under the dash for all the rear wiring.
When I have used the bed for a ground, I have had to occasionally bolt a jumper wire from the bed to the frame. And then you need to make sure the ground for the frame up front is good. On the gas trucks they had a bare spot on the large ground wire and had a metal clamp that bolted to the frame as it made it's way from the battery neg to the engine block.
Not sure what they did on the diesels, I know they have a large ground wire from each battery going to the front corners of the block on each side. But this is no good for the frame or the body, the engine/tranny/trans/rearend are all mounted in rubber mounts. And the body is mounted on rubber mounts. The factory had ground jumpers here and there to ground everything, but sometimes they get left off or get corroded.