To be honest, I have driven all 3 major types of full-sized "trucks", in different configurations. I have driven piuck-ups, vans and mid, and full sized SUV's. The trucks have been open, 2 and 4 wheel drive, 1 with a "topper" (midwest name for a truck cap), and it also had a soft tonneau cover on it. 2 different full sized vans, a 5.9 Durango and my 6.0 Excursion. 2 of the trucks have only been driven with an open bed, a 73 F-250 2wd RC 390 V-8 and a 97 F-250 EC 4x4 5.4 V-8. These 2 trucks have gotten 15 and below for mileage. A 3rd truck an 83-F150 4x4 RC 351 V-8 was close to the same, this truck had a topper, and a tonneau cover. It was driven in all 3 configurations, alot, topper, tonneau cover, and open. Not much difference in economy between the 3... 2 E-150 Vans, 2wd, both customized vans, both with 302 V-8 (one carb, one EFI) and these would get consistently ~ 15 with a high on a long trip of 18. A 2000 Durango 4x4 360 V-8 and the best it would do is 13. And my 03 Excursion 4x4 6.0 PSD will get ~ 20 on the highway on a trip. I agree with most on here, it is not the configuration of the vehicle that gets economy (if you think about it, a truck with a topper, an SUV an a van are the same basic shape), it is the configuration of the gearing, power plant, the drivers right foot, and weather conditions. For 1 holiday trip, topper or no topper, I don't not think you see enough difference in economy to matter. The speed, gearing, weather, weight of the truck, and how hard you drive it will matter more. If you were wanting to hypermile, all the time there are things you can do to help. There is a guy that lives in the same town that I do, I believe his name is Dave Sopnagle (not spelled right) that has been on different boards and does hypermile with his truck. He has a 99 F-250, 2wd, RC 7.3 PSD. He has changed the rear gear to a 3.08, has changed the mirrors, has the truck sitting as low a possible, stock, he has made a cover, that surrounds the cab, and tapers down to the tailgate, he has put a "fairing" on the front to bring the nose closer to the ground... and he gets mid 20's..... but it has taken alot of work to get there...... I would say for a holiday trip, put the cap on it, and enjoy the clean, dry bed to haul your luggage and gifts in.