it won't bolt to the 7.3 transmission, but it can be had with a medium duty manual 5 or 6 speed, and 8, 9 and 13 speed if you want to run on board air (be pretty wild having an f250 with a 13 direct in it lol). a 7.3 IDI weighs in somehweres around 1000 - 200 pounds? A DT466 tips the scales at around 1400 - 1500 pounds. Mechanics I talked to said an f250/350 frame would hold a DT466 without any stregnth issue.....be no different than having a diesel F250/350 with an 8 foot plow hanging off the front of it in my opinion.