How much of a lift would you need over stock to run the 37's?
Mine is bone stock suspension and the tires don't rub anywhere. If they did I'd have cut the offending piece off but they don't. I'd guess they may have rubber the front edge of the fender but I cut that off due to one fender having damage there.
Will they clear a stock bed uncut I couldn't tell ya that as I have never had a bed on this truck.
As for a shackle reversal limiting anything that's completely wrong. My guess is it was easier to run forward shackles on the 350 since the 250 had to have them by design. Saved a big step in the manufacturing of trucks. Look at 79 and 99 trucks, they both run rear shackles and neither generation had ttb in 4x's.