Yes, you can drop your axle ratio. It's not a big deal.
I have 3.55's in my 250, and she will still pull 10-15k. Without issue. You will not get as good mileage while towing tho.
It's a trade off, if you mostly tow or haul heavy with the truck. You're getting better mileage with the 4.10's. If you mostly drive it empty or light, and occasionally tow or haul heavy. You'll like the 3.55's
It'll likely be cheapest and easiest to simply buy a 10.25 with the 3.55's already in it from the JY, than trying to change the ring and pinion.
Or you could put a OD unit in it. Then you has both!