I think you're big problem is going to be all the electronics. For sure an automatic trans is going to be problematic unless you thrown a C6 in, or maybe an E4OD with a idi ECU. Thing is all the computer systems on modern stuff all work together so it's hard to just take one out without causing problems in other systems. ABS is the only thing I can think of that you'd really want to work, but I'm not sure what else might wind up being a headache.
All the structural stuff would be work too - engine mounts, clearances, radiator hoses, fuel lines, throttle cable, etc. All probably things that could be made to work, but at what cost in time and effort?
Interesting project for sure, but not sure if it's worth the work.