one thing to keep in mind, I have close to a million miles of logbook time on a NA F450 IDI. I've also driven bigger and older and more underpowered than my F450 (1959 Chevy Spartan 90) and I've driven the big horse 18 speed monsters. There is nothing worse than a tow unit that has improperly matched power/trans/rear to the target weight load you're hauling.
The Nostromo(my '92 F350) is clear proof if you are hauling up to a 15k trailer, the truck performs effortlessly and as a result, the driver is not as tore up when he gets to the drop. Stock motor, turned up pump, ATS 093 aftermarket, 4in straight exh, stock clutch and ZF5, 4.10LS rear riding on 215/85/16's is the perfect combo.....for this truck. What do I look for? When I let out the clutch in 1st gear, I like being able to just nudge the throttle gently to prevent load up. From there, I want to roll on the throttle and have the torque take me up to the next gear. Shift at 2200 rpms. Take it up a little higher for 3rd and 4th. usually 2600 rpm for shifting. When I get to 5th I don't mind taking it up to redline as long as the conditions allow. The truck cruises effortlessly on flatlands and up the Grapevine north or southbound. only time I drop gears is when there is traffic.
My F450's are driven the same way other than I am limited to 75mph due to running out of rpms due to gearing. When I hit the hills, I'm dropping gears. no choice, it's the nature of the beast. Ironically, my IH 4700's with the vaunted DT466 is no better. as a result, as long as the combo matches the load weight, you're golden.
nice thing about the F350 is the suspension isn't beating you to death like the bigger boys are guaranteed to do to you.