Science is your friend. Measuring known conditions is also the only way to go. Put an in-cab fuel pressure gauge on the line between the IP and the filter header, and I'd be willing to bet you will see your problem as the needle drops to zero. At higher fuel load the IP will attempt to deliver fuel to the cylinders at a rate greater than the fuel can be taken in when there is insufficient delivery. It will basically empty out the supply line just like if you disconnected it.