Never tried it. I have used Mobil synthetic on my wheel bearings with good success in the past. I had a wheel bearing fail on my in West Virginia heading to Mel's rally in 2011.
I changed it out in a parking lot of a school with a claw hammer and 1/2 inch drive ratchet for a punch. Real fun.
Anywho, I packed the new bearings with the syn Mobil grease and they looked great when I checked them last. Likely close to 100K on that set of bearings now.
Heath