I have noticed this on several IDI's. While maintaining a steady throttle input (not necessarily WOT, but enough to create steady smoke), there will be occasional puffs of heavier smoke that come and go. Never did figure it out, this was on new or fresh pumps, from reputable pump builders.
A thought was, CDR gasses accumulating and dispersing into the intake irregularly, but that really shouldn't be happening unless the CDR was pulling oil from the valley, which these trucks were not doing.
Or, fuel pressure changes/fluttering with a mechanical fuel pump, changing the timing rapidly. But mine have all been on E fuel pumps and steady pressure...so that kinda rules that out to.