Lots of people go to Th400's for high HP apps rather than staying with the C6, which is highly unwarranted, it's just like the other transmissions though, only certain builders know how to build them. That said, I am putting a 4R100 spec E4OD behind my 460...
As for a C6 behind an IDI, slow, lots of slip, and with 4.10's, highway speeds are painful, that said, they are bombproof.
This 88 F350 weighs 23K full of de-ice fluid, and it happily has functioned with lots of low speed forward/reverse shuttle shifting for 5000 miles, not a big mileage number, but take into fact that it changes direction 6 times within 200 feet of travel to spray an airplane, 95% of the time it is at max gcwr, and until 2009 it had never seen low range.
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The tag axle is a 10,000lb trailer unit, and the bumpers are filled with cement...
As for drivetrain power loss, the Allison is downright alarming. We recently had a mobile dyno brought in to the local car show, and the GM dealer brought out a 2011 2500HD with the Dirtymax, they were having issues with the tuner they had installed on it, and it ran 3 runs at bone stock levels.
Keeping in mind it is rated at 397 hp/765tq, it put down an average of 253/453 to the tires in stock trim, tuned it bumped up to 345/607, but it was still quite surprising just how much that driveline chews up.
My buddy's very mildly turned up 92 Cummins made 256/540 through a NV4500, another friends 07 with a smarty, muffler delete, and AFE intake made 457/839 through a 48RE with 37 inch tires...