I dont think the injectors are costing you that much in MPG. I think it might be one of the factors that is contributing. How does it cold start? I know cold is relative, but after sitting 24 hours how does it start up? That could help us internet diagnose timing problems, injector/fueling problems, bad glow plugs (not the problem here), and or bad compression (if one cylinder takes more than a few seconds to light, theres a problem *This could also be glow plugs, but generally if it takes a long time to fire off on one or more cylinders, its more compression related*).
So I disagree with everyone, #12 isnt THE problem, it could be the problem, but probably is more of a culmination of things.
I also dont think your water temp is causing the MPG loss, perhaps if it was on the low side it would drop a little, but generally the hotter these run, the better they run (to a certain extent, and 220* is probably around the threshold of the tapering off of MPG).